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"The Spellman Files" by Lisa Lutz is the start of a very funny series featuring Izzy Spellman (and her anger management issues) and the rest of her family of private detectives. If you like your mysteries well-laced with humor, and your heroines feisty, you might like the following titles:
"Agnes and the Hitman" by Jennifer Crusie. Agnes Crandall's life goes awry when a dognapper invades her kitchen one night, seriously hampering her attempts to put on a wedding that she's staked her entire net worth on. Then a hero climbs through her bedroom window.His name is Shane, no last name, just Shane, and he has his own problems: he's got a big hit scheduled, a rival trying to take him out, and an ex-mobster uncle asking him to protect some little kid named Agnes. (from summary) [Actually, I think you'd like any Crusie title. She kind of got stuck in the "pink ghetto" of Romance, but her books are very funny contemporary fiction with a little steamy sex thrown in]
"Sleeping With the Fishes" by MaryJanice Davidson. Fred is not your ordinary mermaid. She's not blonde. She's not buxom. And she's definitely not perky. (from summary) [This is the first in a series featuring Fred the Mermaid. Davidson has two other series you would probably like - the "Undead" series featuring reluctant vampire Betsy Taylor and the "Royal Alaska" series]