Block was born in Los Angeles, sometimes known as "Shangri-L.A.", other times "Hell-A", depending on how the day is going. The daughter of a poet and painter, she attended the University of California at Berkeley. Francesca was a riot grrl before the term had even been invented. She read the novels of Gabriel Garcia Marquez while at college; his magical realism became a major influence. Block's work is grounded in urban realities, though she sees pixies and genies in that "jasmine-scented, jacaranda-purple, neon sparked city". She missed Los Angeles, and wrote her first novel to cure homesickness. That novel was Weetzie Bat, and it made a big wet splash in Young Adult literature.