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John Dies at the End by David Wong: "This may be the story of John and David, a drug called soy sauce, and other-worldly beings invading the planet. Or, it may be the story of two beer-drinking friends who live in an unnamed Midwestern town and only think something horrific is going on. But the important thing is, according to the narrator, "None of this is my fault." (Book description)
If you like this novel for the mix of science fiction and satire, you may also enjoy:
Agent to the Stars by John Scalzi
The space-faring Yherajk have come to Earth to meet us and to begin humanity's first interstellar friendship. There's just one problem: They're hideously ugly and they smell like rotting fish. So getting humanity's trust is a challenge. The Yherajk need someone who can help them close the deal. Enter Thomas Stein, who knows something about closing deals. He's one of Hollywood's hottest young agents. But although Stein may have just concluded the biggest deal of his career, it's quite another thing to negotiate for an entire alien race. To earn his percentage this time, he's going to need all the smarts, skills, and wits he can muster.
Bloodsucking Fiends (A Love Story #1) by Christopher Moore
A budding young writer falls in love with a vampire. He is Tommy of Indiana who moved to San Francisco in search of inspiration and is working in a supermarket. Shopping there is Jody, a secretary still trying to adjust to her new vampire status, after being bitten by one on her way home.