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John Dies at the End by David Wong: "This may be the story of John and David, a drug called soy sauce, and other-worldly beings invading the planet. Or, it may be the story of two beer-drinking friends who live in an unnamed Midwestern town and only think something horrific is going on. But the important thing is, according to the narrator, "None of this is my fault." (Book description)
If you like this novel for the mix of science fiction and satire, you may also enjoy:
Agent to the Stars by John Scalzi
The space-faring Yherajk have come to Earth to meet us and to begin humanity's first interstellar friendship. There's just one problem: They're hideously ugly and they smell like rotting fish. So getting humanity's trust is a challenge. The Yherajk need someone who can help them close the deal. Enter Thomas Stein, who knows something about closing deals. He's one of Hollywood's hottest young agents. But although Stein may have just concluded the biggest deal of his career, it's quite another thing to negotiate for an entire alien race. To earn his percentage this time, he's going to need all the smarts, skills, and wits he can muster.
Bloodsucking Fiends (A Love Story #1) by Christopher Moore
A budding young writer falls in love with a vampire. He is Tommy of Indiana who moved to San Francisco in search of inspiration and is working in a supermarket. Shopping there is Jody, a secretary still trying to adjust to her new vampire status, after being bitten by one on her way home.
Cowboy Feng's Space Bar and Grille by Steven Brust
Cowboy Feng's Space Bar and Grille serves the best matzoh ball soup in the Galaxy, and hires some of the best musicians you'll ever hear. It's a great place to visit, but it tends to move around-just one step ahead of whatever mysterious conspiracy is reducing whole worlds to radioactive ash. And Cowboy Feng's may be humanity's last hope for survival.
The Coyote Kings of the Space-Age Bachelor Pad by Minister Faust
Hamza and Yehat are The Coyote Kings-best friends, one a disgruntled dishwasher and the other a video store clerk, but each brilliant in his own right. Yehat builds prototypes of space-age inventions in his spare time, while Hamza, a former English honors student who was kicked out of the university, writes lush, lyrical poems when he's not blocked-which, these days, is nearly always. When the gorgeous, mysterious Sherem shows up in E-Town decked out in desert finery, Hamza's creative spark is ignited. Who is this sophisticated woman that speaks arcane African tongues, quotes from obscure comics and Star Wars movies, yet seems somehow too ethereal for the world Hamza inhabits? And what is the lost artifact that she and a cast of coiffed collectors and criminal cultists so desperately seek? As Hamza falls blindly in love with Sherem, little does he know that he and Yehat play the biggest part of all in the recovery of the ancient relic-and in the future of all living beings.
Galapagos by Kurt Vonnegut
A small group of apocalypse survivors stranded on the Galapagos Islands are about to become the progenitors of a brave new human race.
Gun, With Occasional Music by Jonathan Lethem
Gumshoe Conrad Metcalf has problems-there's a rabbit in his waiting room and a trigger-happy kangaroo on his tail. Near-future Oakland is a brave new world where evolved animals are members of society, the police monitor citizens by their karma levels, and mind-numbing drugs such as Forgettol and Acceptol are all the rage. Metcalf has been shadowing Celeste, the wife of an affluent doctor. Perhaps he's falling a little in love with her at the same time. When the doctor turns up dead, our amiable investigator finds himself caught in a crossfire between the boys from the Inquisitor's Office and gangsters who operate out of the back room of a bar called the Fickle Muse.
Hitchhiker’s Guide to the Galaxy by Douglas Adams
Seconds before the Earth is demolished to make way for a galactic freeway, Arthur Dent is plucked off the planet by his friend, Ford Prefect, an alien who has been posing as an out-of-work actor for the last fifteen years while researching material for the revised edition of ‘The Hitchhiker's Guide to the Galaxy’.
The Hollow Chocolate Bunnies of the Apocalypse by Robert Rankin
Jack gets lost on his way to the city to make his fortune. He finds himself in Toy City, where a serial killer is on the loose. One by one, the old rich nursery rhyme characters, who made millions from royalties on their best-selling rhymes, are being slaughtered. Jack and Eddie Bear, a battered teddy bear, are challenged to solve the mystery.
Life, Liberty, and the Pursuit of Sausages by Tom Holt
Polly, an average, completely ordinary property lawyer, is convinced she's losing her mind. Someone keeps drinking her coffee. And talking to her clients. And doing her job. And when she goes to the dry cleaner's to pick up her dress for the party, it's not there. Not the dress - the dry cleaner's. And then there are the chickens who think they are people. Something strange is definitely going on - and it's going to take more than a magical ring to sort it out.
One Bloody Thing After Another by Joey Comeau
This is a book about Jackie, whose mother died of cancer. But her mother's still around, glowing in the dark and vomiting in the toilet. Jackie has a crush on Ann, whose own mother and sister have turned into violent creatures that have to be kept locked up in the basement. Charlie is an old man. His building is haunted by a headless ghost who wants something, but Charlie has no idea what. A weird, wonderful and moving horror story.
Monster by A. Lee Martinez
Monster, who runs an agency that deals with mythological pests, encounters Judy when he deals with a yeti she finds at the supermarket where she works, and together they battle an evil being disguised as the local crazy cat lady.
To Say Nothing of the Dog by Connie Willis
Ned Henry is badly in need of a rest. He's been shuttling between the 21st century and the 1940s searching for a Victorian atrocity called the bishop's bird stump. It's part of a project to restore the famed Coventry Cathedral, destroyed in a Nazi air raid over a hundred years earlier. But then Verity Kindle, a fellow time traveler, inadvertently brings back something from the past. Now Ned must jump back to the Victorian era to help Verity put things right--not only to save the project but to prevent altering history itself.
Shambling Towards Hiroshima by James K. Morrow
In the summer of 1945, war is reigning in the Pacific Rim while Syms Thorley continues his life as a B-movie actor. But the Navy would like to use Thorley in their top-secret Knickerbocker Project, putting the finishing touches on the ultimate biological weapon: a breed of gigantic, fire-breathing, mutant iguanas. Thorley must don a rubber suit that will transform him into the merciless Gorgantis, and star in a film that simulates the destruction of a miniature Japan. If the demonstration succeeds, the Japanese will surrender, sparing thousands of lives; if it fails, the mutant lizards will be unleashed.